Examples of use of CD28
1. TGN1412 was known to activate CD28 strongly, the scientists said.
2. When scientists artificially stimulated CD28 on previously activated T cells, it caused the cells to migrate from the blood stream into organs where there was no infection, causing significant tissue damage.
3. Stimulating the molecule CD28 on T cells, which mediate the immune response, can have an adverse effect if the cells have in the past been activated and altered by infection or illness, the study shows.